Cell division cycle 25 (Cdc25) is a key regulator of Cyclin-dependent kinase 1 (Cdk1) during the cell cycle. The activation and regulation of Cdc25 are crucial for the entry into mitosis. Given below are a few statements about Cdc25 and its role during the cell cycle:
A. Cdc25 is activated by phosphorylation events mediated by Cdk1-Cyclin B complex during the G2/M transition.
B. Cdc25 removes inhibitory phosphates from Cdk1, facilitating its activation and promoting mitotic entry.
C. Cdc25 is inactivated by phosphorylation through Chk1/Chk2 in response to DNA damage, preventing premature mitotic entry.
D. Cdc25 is degraded by proteolysis during the metaphase-to-anaphase transition to ensure proper cell cycle progression.
Which one of the following combinations represents all the correct statements?