A cancer clinic is treating four unrelated patients suffering from chronic myelogenous leukemia. A researcher sequences the Philadelphia chromosome from the leukemic cells of these patients and makes the following statements:
A. The DNA sequence was identical in the translocation breakage and rejoining (TBR) sections in all leukemic cells in all 4 patients.
B. The DNA sequence was identical in all leukemic cells from patient 1 , but every patient had a different TBR sequence.
C. All patients have translocations between long arms of chromosomes 9 and 22.
D. All patients have translocations between long arm of chromosome 9 and short arm of chromosome 22.
Which one of the following options represents a combination of all correct statements?
1
A and D
2
B and C
3
B and D
4
A and C