The following experimental manipulations were carried out with Xenopus embryo.
Manipulation X: Exposure to ultra violet radiation leading to the failure of cortical rotation.
Manipulation Y: Gastrulae treated with lithium chloride, an agonist of canonical Wnt signaling.
The following statements were made with respect to the above manipulations and genes involved in setting up dorso-ventral polarity in amphibians.
A. The phenotype obtained due to manipulation X can be rescued by injection of noggin in 1-cell embryo
B. Chordin mRNA will be enriched in embryos of manipulation X as compared to those of manipulation Y
C. Injection of cDNA for chordin into ventral blastomeres leads to the induction of a secondary axis.
D. Experimentally depleting β-catenin transcripts in 1-cell embryo by antisense oligonucleotides leads to phenotype similar to that obtained from manipulation X.
Which one of the following options represents all correct statements?