Which one of the following statements about stem cells is correct? 

1
Stem cells cannot be maintained in culture since they require a distinct in vivo microenvironment known as niches. 
2
During asymmetric stem cell division, only one of the daughter cells is retained as a stem cell. 
3
Stem cell derived transit‐amplifying cells are differentiated cells which retain the capacity to divide further. 
4
Hematopoietic stem cells (HSCs) are totipotent stems cells. 

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