Which one of the following statements is correct about solute transport across membranes?

1
Passive transporters decrease the activation energy and does not facilitate the transport of polar compounds
2
The direction in which a charged solute tends to move spontaneously across a membrane does not depend on the electrical gradient across the membrane
3
All ABC transporters do not have nucleotide binding domain
4
P-type ATPases get reversibly phosphorylated as a part of transport cycle

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