Sickle-cell anemia is a disease characterised by the patient's erythrocyte, having a characteristic sickle or crescent shape.
Select the correct statement about the disease -
1
Deletion of glutamic acid from the 6th position of β-chain.
2
Substitution of hydrophobic residue by a polar one.
3
Substition of polar residue by a hydrophobic one.
4
Substitution of valine residue by a glutamic acid one.