Teaching MPPSC Assistant Professor Mock Test Series 2025 Life Sciences Cell Communication and Cell Signaling
The phosphoinositide signaling pathway involves the activation of phospholipase C-β (PLC-β) by G protein-coupled receptors (GPCRs) through Gq. This leads to the production of multiple second messengers. The following statements describe steps and functional characteristics of this pathway, one of which is incorrect. Select the INCORRECT option:
1
IP3 binds to the IP3 receptor on the endoplasmic reticulum, triggering the release of Ca2+ ions into the cytosol.
2
DAG activates protein kinase C (PKC) in a Ca2+-dependent manner, leading to downstream phosphorylation of target proteins.
3
The phosphoinositide signaling pathway exclusively uses Gq for activation of PLC-β, and no other G protein subtypes are involved in this pathway.
4
The increase in cytosolic Ca2+ leads to the activation of calmodulin, which in turn activates calcium/calmodulin-dependent protein kinases (CaMKs) involved in transcriptional regulation.