Which of the following best describes the function of cyclins during the cell cycle?

1
Cyclins trigger the activation of apoptosis when DNA damage is detected 
2
Cyclins bind to cyclin-dependent kinases (CDKs) to promote progression through specific cell cycle checkpoints
3
Cyclins prevent the transition from G1 to S phase by inhibiting CDK activity
4
Cyclins function to replicate DNA during the S phase of the cell cycle

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