Select the correct combination of statements about cell cycle progression and regulation:

A. Cyclin B forms a complex with CDK1 to drive cells into mitosis by phosphorylating key mitotic proteins.

B. Retinoblastoma protein (Rb) inhibits E2F activity, preventing progression from G1 to S phase until phosphorylated by G1/S-Cdks.

C. Anaphase-promoting complex (APC/C) triggers sister chromatid separation by targeting securin for degradation via ubiquitination.

D. CDK inhibitors such as p21 and p27 directly promote the activation of CDK1 during the G2/M transition.

1
A,B and C
2
B and D
3
A and D
4
A,B and D

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