In Xenopus embryos, β-catenin plays an important role in the Dorsal/Ventral axis development. What would you expect if the endogenous glycogen synthase kinase 3 (GSK3) is knocked out by a dominant-negative form of GSK3 in the ventral cells of the early embryo?
1
Blocking of GSK3 on the ventral side has no effect. A normal embryo will form.
2
The resulting embryo will only have ventral sides.
3
A second axis will form.
4
The dorsal fate is suppressed.