Parasite numbers in the blood of a patient with Trypanosoma brucci (Sleeping sickness) shows the following pattern:

Parasites isolated from population 1 and 2 were found to be antigenecially non - cross reactive. The parasite distribution seen may be due to: 

1
Change in gene expression 
2
Loss of antigenic epitopes
3
Post-translational modification of antigen 
4
Antigenic switching

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