What is the significance of the isomerization of glucose 6-phosphate to fructose 6-phosphate for the progression of glycolysis?

1
 As functional groups, ketones are more reactive than aldehydes
2
Cleavage of glucose 1,6-bisphosphate will not yield dihydroxy acetonephosphate and glyceraldehyde 3-phosphate
3
The carbonyl group at carbon-2 (C-2) in fructose facilitates the cleavage of the bond between C-3 and C-4
4
Phosphorylation of glucose 6-phosphate to glucose 1,6-bisphosphate is irreversible

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