Which one of the following statements with respect to development in amphibians is correct?

1
Gastrulation begins with the invagination of bottle cells, followed by coordinated involution of the mesodermal precursors and the epiboly of the prospective ectoderm
2
The organizer induces the Nieuwkoop centre
3
The organizer is formed by the accumulation of B-catenin
4
In the absence of BMP inhibitors ectodermal cells form neural tube 

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