Proteins and nucleic acids adopt specific three-dimensional structures that are crucial for their function. Which of the following statements accurately describes a principle or characteristic of protein or nucleic acid conformation?

1
Proteins fold into their native structures spontaneously, solely under the direction of their primary amino acid sequences, without any external guidance or energy input.
2
Nucleic acids, unlike proteins, lack a secondary structure and primarily exist in a single-stranded form that does not participate in cellular functions.
3
Alpha-helices and beta-sheets are examples of secondary structure in nucleic acids, predominantly contributing to their three-dimensional architecture.
4
The folding of proteins into their three-dimensional structures is influenced by non-covalent interactions, including hydrogen bonds, ionic bonds, van-der Waals forces, and hydrophobic interactions.

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