Below, a passage is given with five blanks labeled (A)-(E). Below the passage, five options are given for each blank. Choose the word that fits each blank appropriately in the context of the passage, and mark the corresponding answer.

Until recently, virtually all experts agreed that schizophrenia is always, or almost always, marked by a steady (A) _______ progression. But is this bleak forecast warranted? Certainly, schizophrenia is a severe condition. Its victims, who make up about 1 percent of the population, experience a loss of contact with reality that puts them at a (B) _______ risk of suicide, unemployment, relationship problems, physical ailments, and even early death. Those who (C) _______ substances are also at risk for committing violent acts against others. (D) _______ to popular belief, people with schizophrenia do not have multiple personalities, nor are they all (E) _______ alike—or victims of poor parenting.